They can sense when something is not resonating and adjust in real-time accordingly. Like stage actors and musicians, the storyteller is also reacting to the emotions of the audience. The storyteller reads the audience, elicits reactions, and is in many ways a mentor or guide on taking people on a journey of imagination. We can see this in contemporary oral storytelling. The oral storyteller formed a relationship and shared experience with the audience. The audience was not at all removed from the teller. LA: The feedback loop between the traditional oral storyteller and the audience is intimate and instant. Cave paintings, like this one in Altamira, Spain, are some of our earliest evidence of the human drive to capture experience through story
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The non-amyloidogenic pathway is mediated by α and γ-secretases and gives rise to a large fragment known as soluble APPα (sAPPα) and a small 3 kDa peptide known as p3. Processing of APP occurs by two major pathways, non-amyloidogenic pathway and amyloidogenic pathway. It is known that there are three major isoforms, APP695, APP751 and APP770, and are generated from alternative splicing of common precursor mRNA.
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